In clinical trials, the most common adverse reactions (at least 5% more frequent on AVONEX than on placebo) were flu-like symptoms.
Advise your patients to1-2:
Stay well hydrated
Take analgesics and/or antipyretics on treatment days
Experiment with different times of day for their injection
Keep a journal to note how long after their injection any side effects occur, how much water they drink, and any pain relievers they take
To reduce the incidence and severity of flu-like symptoms that may occur when initiating AVONEX therapy at a dose of 30 mcg, AVONEX may be started at a dose of 7.5 mcg and the dose may be increased by 7.5 mcg each week for the next three weeks until the recommended dose of 30 mcg is achieved.
An AVOSTARTGRIP® Titration Kit containing 3 titration devices can be used for titration and is to be used only with AVONEX prefilled syringes.
Support for your patients
Nurse Educators, working on behalf of Biogen, can give your patients information about common side effects of AVONEX and provide them with mitigation strategies.
Your patients can call Nurse Educators Monday through Friday, 8:30 am to 8:00 pm ET at 1-800-456-2255. Hablamos español.