Managing common AVONEX side effects

Flu-like symptoms1

In clinical trials, the most common adverse reactions (at least 5% more frequent on AVONEX than on placebo) were flu-like symptoms.

  • Symptoms can include chills, fever, myalgia, and asthenia occurring within hours to days following an injection
  • Most people who take AVONEX have flu-like symptoms early during the course of therapy
  • Usually, these symptoms last for a day after the injection
  • For many people, these symptoms lessen or go away over time

Mitigation strategies for flu-like symptoms

Advise your patients to1-2:

Stay well hydrated

Take analgesics and/or antipyretics on treatment days 

Experiment with different times of day for their injection

  • Symptoms may peak at different times depending on the individual 

Keep a journal to note how long after their injection any side effects occur, how much water they drink, and any pain relievers they take

Dose titration1

To reduce the incidence and severity of flu-like symptoms that may occur when initiating AVONEX therapy at a dose of 30 mcg, AVONEX may be started at a dose of 7.5 mcg and the dose may be increased by 7.5 mcg each week for the next three weeks until the recommended dose of 30 mcg is achieved.

An AVOSTARTGRIP® Titration Kit containing 3 titration devices can be used for titration and is to be used only with AVONEX prefilled syringes.

Support for your patients

Nurse Educators, working on behalf of Biogen, can give your patients information about common side effects of AVONEX and provide them with mitigation strategies.

Your patients can call Nurse Educators 24/7 at 1-800-456-2255. Hablamos español.

Getting started

Get your patients started on therapy with the AVONEX Start Form

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One injection, once a week1

Explore once-a-week dosing and different dosage forms for your relapsing MS patients

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